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1996-03-30
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Document 1000
DOCN M9651000
TI Tuberculosis among urban health care workers: a study using restriction
fragment length polymorphism typing.
DT 9505
AU Sepkowitz KA; Friedman CR; Hafner A; Kwok D; Manoach S; Floris M;
Martinez D; Sathianathan K; Brown E; Berger JJ; et al; Division of
Infectious Diseases, Cornell University Medical; College, New York, New
York, USA.
SO Clin Infect Dis. 1995 Nov;21(5):1098-101. Unique Identifier : AIDSLINE
MED/96125988
AB Cases of tuberculosis identified during 1992-1994 through an active
tuberculosis surveillance network among six hospitals that serve New
York City (the TBNetwork) were analyzed according to the occupational
status of the patients. Clinical data were obtained by review of medical
records, and restriction fragment length polymorphism (RFLP) typing of
Mycobacterium tuberculosis isolates was performed. No known nosocomial
outbreaks of tuberculosis occurred at these hospitals in the study
period. Occupational status was known for 142 of 201 patients whose
isolates were available for strain typing. Patients infected by
organisms with a clustered strain typing pattern, as determined by RFLP
analysis, were presumed to have recently acquired disease. RFLP typing
revealed that isolates from 13 (65%) of 20 health care workers and 50
(41%) of 122 non-health care workers had a clustered RFLP pattern. The
strains infecting eight (89%) of nine health care workers seropositive
for human immunodeficiency virus (HIV) had a clustered RFLP pattern.
Multivariate analysis of 75 patients with known HIV and occupational
status revealed that HIV status (P = .03) and health care worker status
(P = .02; RR = 2.77) were independent risk factors for a clustered RFLP
strain. These findings suggest that many of the apparently sporadic
cases of tuberculosis among health care workers may be due to
unrecognized occupational transmission.
DE Adult Bacterial Typing Techniques Cluster Analysis Epidemiology,
Molecular Female *Health Personnel Human Male Middle Age
Mycobacterium tuberculosis/CLASSIFICATION/GENETICS/ISOLATION & PURIF
New York City/EPIDEMIOLOGY Occupational
Diseases/*EPIDEMIOLOGY/MICROBIOLOGY Polymorphism, Restriction Fragment
Length Risk Factors Support, Non-U.S. Gov't Tuberculosis,
Pulmonary/*EPIDEMIOLOGY/MICROBIOLOGY/TRANSMISSION Urban Population
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).